Publications

Journal articles of the Research Group FOR1202 "Mechanisms of Persistence of Hepatotropic Viruses"


2012

Identification of naturally processed hepatitis C virus-derived major histocompatibility complex class I ligands. Wölk B, Trautwein C, Büchele B, Kersting N, Blum HE, Rammensee HG, Cerny A, Stevanovic S, Moradpour D, Brass V. PLoS One. 2012;7(1):e29286.


2011

Schulze A, Mills K, Weiss TS, Urban S. 2011. Hepatocyte polarization is essential for the productive entry of the hepatitis B virus. Hepatology. doi: 10.1002/hep.24707. [Epub ahead of print]

Thimme R, Binder M, Bartenschlager R. 2011. Failure of innate and adaptive immune responses in controlling hepatitis C virus infection. FEMS Microbiol Rev. doi: 10.1111/j.1574-6976.2011.00319.x. [Epub ahead of print]

Neumann-Haefelin C, Oniangue-Ndza C, Kuntzen T, Schmidt J, Nitschke K, Sidney J, Caillet-Saguy C, Binder M, Kersting N, Kemper MW, Power KA, Ingber S, Reyor LL, Hills-Evans K, Kim AY, Lauer GM,Lohmann V, Sette A, Henn MR, Bressanelli S, Thimme R, Allen TM. 2011. Human leukocyte antigen B27 selects for rare escape mutations that significantly impair hepatitis C virus replication and require compensatory mutations. Hepatology. 54(4):1157-66.

Klenerman P, Thimme R.2011. T cell responses in hepatitis C: the good, the bad and the unconventional. Gut. Aug 28. [Epub ahead of print]

Binder M, Eberle F, Seitz S, Mücke N, Hüber CM, Kiani N, Kaderali L, Lohmann V, Dalpke A, Bartenschlager R. 2011. Molecular mechanism of signal perception and integration by the innate immune sensor retinoic acid-inducible gene-I (RIG-I).J Biol Chem.5; 286(31):27278-87.

Schmidt J, Neumann-Haefelin C, Altay T, Gostick E, Price DA, Lohmann V, Blum HE, Thimme R.2011. Immunodominance of HLA-A2 restricted hepatitis C virus-specific CD8+ T cell responses is linked to naive precursor frequency.J Virol. 85(10):5232-6.

Jo J, Lohmann V, Bartenschlager R, Thimme R.2011. Experimental models to study the immunobiology of hepatitis C virus.J Gen Virol. 92(Pt 3):477-93.

2010

Köck J, Rösler C, Zhang J-J, Blum HE, Nassal M, Thoma C. 2010.Generation of Covalently Closed Circular DNA of Hepatitis B Viruses via Intracellular Recycling Is Regulated in a Virus Specific Manner. PLoS Pathog 6: e1001082. doi:10.1371/journal.ppat.1001082

Neumann-Haefelin C, Timm J, Schmidt J, Kersting N, Fitzmaurice K, Oniangue-Ndza C, Kemper MN, Humphreys I, McKiernan S, Kelleher D, Lohmann V, Bowness P, Huzly D, Rosen HR, Kim AY, Lauer GM, Allen TM, Barnes E, Roggendorf M, Blum HE, Thimme R. 2010. Protective effect of human leukocyte antigen B27 in hepatitis C virus infection requires the presence of a genotype-specific immunodominant CD8+ T-cell epitope. Hepatology. 51(1):54-62.


2009

Bellecave P, Gouttenoire J, Gajer M, Brass V, Koutsoudakis G, Blum HE, Bartenschlager R, Nassal M, Moradpour D. 2009. Hepatitis B and C virus coinfection: a novel model system reveals the absence of direct viral interference.Hepatology. Jul;50(1):46-55

Jo J, Aichele U, Kersting N, Klein R, Aichele P, Bisse E, Sewell AK, Blum HE, Bartenschlager R, Lohmann V, Thimme R. 2009. Analysis of CD8+ T-cell-mediated inhibition of hepatitis C virus replication using a novel immunological model. Gastroenterology. Apr;136(4):1391-401.

Dazert E, Neumann-Haefelin C, Bressanelli S, Fitzmaurice K, Kort J, Timm J, McKiernan S, Kelleher D, Gruener N, Tavis JE, Rosen HR, Shaw J, Bowness P, Blum HE, Klenerman P, Bartenschlager R, Thimme R. Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27-restricted human immune response. J Clin Invest. Feb;119(2):376-86.

Welsch S, Miller S, Romero-Brey I, Merz A, Bleck CK, Walther P, Fuller SD, Antony C, Krijnse-Locker J, Bartenschlager R. 2009. Composition and three-dimensional architecture of the dengue virus replication and assembly sites. Cell Host Microbe. 5:365-75